Zinc finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF57 (Zinc finger protein 57), also known as ZNF424 (Zinc finger protein 424) or ZFP57, is a 555 amino acid member of the Krüppel C2H2-type zinc finger protein family and is thought to be involved in transcriptional regulation, specifically affecting the expression of peripheral nervous system-related genes. Localized to the nucleus, ZNF57 contains one KRAB domain and 13 C2H2-type zinc fingers through which it may convey its DNA, RNA and protein binding capabilities.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of ZNF57 of human origin by WB, IP and ELISA: