Application
Western blot analysis of human recombinant Renin Receptor fusion protein.| Product Name | Renin Receptor Antibody (H-85) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 41-125 mapping within an extracellular domain of Renin Receptor of human origin |
| Modification Notes | The Renin Receptor, also known as ATP6AP2 (ATPase H+-transporting lysosomal accessory protein 2), ATP6IP2 (ATPase H+-transporting lysosomal-interacting protein 2), CAPER or M8-9, is an ATPase-associated protein that functions as a Renin and prorenin cellular receptor. Expressed in the brain, heart, liver, kidney, placenta and pancreas, the Renin Receptor functions to activate ERK 1 and ERK 2, thereby mediating Renin-dependent cellular responses. The Renin Receptor has a subunit that associates with the transmembrane domain of V-type ATPases and interacts with Renin. These interactions increase the catalytic activity of Renin in the Renin-Angiotensin system (RAS), thus upregulating the conversion of angiotensinogen to Angiotensin. Defects in the gene encoding the Renin Receptor are implicated in mental retardation X-linked with epilepsy (MRXE), a syndromatic mental retardation characterized by epilepsy, as well as delays in motor milestones and speech acquisition in infancy. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Renin Receptor of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 41-125 mapping within an extracellular domain of Renin Receptor of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 41-125 mapping within an extracellular domain of Renin Receptor of human origin |
| Entrez Gene | 10159 |
|---|
Application
Western blot analysis of human recombinant Renin Receptor fusion protein.| Application Notes | recommended for detection of Renin Receptor of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
