| Product Name | EPR1 Antibody (C-19) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of EPR1 of human origin by WB, IP and ELISA |
| Modification Notes | Survivin is an anti-apoptotic microtubule-associated protein that is expressed during the G2/M phase of the cell cycle and is downregulated during cancer growth. The gene encoding Survivin has an anti-sense strand which encodes the tumor-associated protein EPR1 (effector cell peptidase receptor 1). Expressed on smooth muscle and vascular endothelial cells, EPR1 functions as a receptor for the coagulation protein Factor X. Via its interaction with Factor X, EPR1 plays a pivotal role in coagulation cascades, generation of intracellular second messengers, signal transduction, endothelial wall formation and modulation of cytokine gene expression. High levels of EPR1 expression are associated with a variety of cancers, including acute leukemia and colon cancer, suggesting that cancer-induced downregulation of Survivin is correlated with increased expression of EPR1, which may participate in cancer growth and metastasis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of EPR1 of human origin by WB IP and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of EPR1 of human origin by WB, IP and ELISA |
| Application Notes | WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
