Application
Western blot analysis of KCNQ2 expression in non-transfected: (A) and human KCNQ2 transfected: (B) 293T whole cell lysates.Application
Western blot analysis of KCNQ2 expression in rat brain tissue extract.Application
Western blot analysis of KCNQ2 expression in EOC 13.31 (A) and EOC 20 (B) whole cell lysates.| Product Name | KCNQ2 Antibody (H-140) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 641-780 mapping near the C-terminus of KCNQ2 of human origin |
| Modification Notes | Epilepsy affects about 0.5% of the world’s population and has a large genetic component. Epilepsy results from an electrical hyperexcitability in the central nervous system. Potassium channels are important regulators of electrical signaling, determining the firing properties and responsiveness of a variety of neurons. Benign familial neonatal convulsions (BFNC), an autosomal dominant epilepsy of infancy, has been shown to be caused by mutations in the KCNQ2 or the KCNQ3 potassium channel genes. KCNQ2 and KCNQ3 are voltage-gated potassium channel proteins with six putative transmembrane domains. Both proteins display a broad distribution within the brain, with expression patterns that largely overlap. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of KCNQ2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 641-780 mapping near the C-terminus of KCNQ2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 641-780 mapping near the C-terminus of KCNQ2 of human origin |
| Entrez Gene | 3785 |
|---|
Application
Western blot analysis of KCNQ2 expression in non-transfected: (A) and human KCNQ2 transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of KCNQ2 expression in rat brain tissue extract.
Application
Western blot analysis of KCNQ2 expression in EOC 13.31 (A) and EOC 20 (B) whole cell lysates.| Application Notes | recommended for detection of KCNQ2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
