Application
Immunofluorescence staining of normal mouse heart frozen section showing cytoplasmic staining.| Product Name | TCL-1A Antibody (M-60) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-60 mapping at the N-terminus of TCL-1A of mouse origin |
| Modification Notes | T-cell Leukemia/Lymphoma Protein 1A (TCL-1A), also known as p14TCL1 is a product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (T-PLL) (1-5). T-PLL is a rare form of mature T-cell leukemia, which is consistently associated with chromosomal rearrangements characterized by the juxtaposition of the TCRA locus on chromosome 14q11 and the TCL1A gene on 14q32.1 (1-5). TCL-1A is a member of a unique family of beta barrel proteins that bind small hydrophobic ligands and function in cell regulation (2). TCL-1A is an all-beta protein containing an eight-stranded antiparallel beta barrel which consists of two four-stranded beta-meander motifs (3). The two motifs are related by a twofold axis and connected by a long loop. TCL-1A forms a tight crystallographic dimer (3). TCL-1A is expressed in pre-B cells, in immature thymocytes, at low levels in activated T cells, and in the cytoplasm (3,4). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TCL-1A of mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-60 mapping at the N-terminus of TCL-1A of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-60 mapping at the N-terminus of TCL-1A of mouse origin |
| Entrez Gene | 21432 |
|---|
Application
Immunofluorescence staining of normal mouse heart frozen section showing cytoplasmic staining.| Application Notes | recommended for detection of TCL-1A of mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
