| Product Name | p-IKKγ Antibody (Ser 376) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to phosphorylated Ser 376 of IKKγ of human origin |
| Modification | Phosphoralated |
| Modification Notes | Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB. IkB kinase å (IKKå), previously designated CHUK, interacts with IkB-å and specifically phosphorylates IkB-å on the sites that trigger its degradation, serines 32 and 36. IKKå appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKKå is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKå, IKK∫ and IKK© (also designated NEMO), and each appear to make essential contributions to IkB phosphorylation. The IKK∫ phosphorylates human IKK© at Ser-31, Ser-43, and Ser-376 following the enforced expression of either the Tax oncoprotein or the type 1 TNF receptor. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of Ser 376 phosphorylated IKKγ of human origin by WB, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to phosphorylated Ser 376 of IKK&gamma of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to phosphorylated Ser 376 of IKKγ of human origin |
| Entrez Gene | 8517 |
|---|
| Application Notes | recommended for detection of Ser 376 phosphorylated IKKγ of human origin by WB, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
