Application
Western blot analysis of ST expression in rat brain tissue extract.| Product Name | ST Antibody (H-115) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 516-630 mapping at the C-terminus of sodium-dependent serotonin transporter of human origin |
| Modification Notes | The members of the G protein coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. Members of the ∫-Arrestin family regulate receptor binding to G proteins. ∫-Arrestins have been found to be located at postsynaptic sites, where they are thought to act in concert with ∫ARK (∫ARK1, also designated GRK 2, or ∫ARK2, also designated GRK 3) to regulate G protein-coupled neurotransmitter receptors. Expression of ∫-Arrestin-1 and b-Arrestin-2 is seen predominantly in spleen and neuronal tissues. It has been shown that ∫-Arrestin-1 expression is modulated by intracellular cAMP, which may be a novel mechanism for the regulation of receptor-mediated responses. The Na/Cl dependent ST (SLC6A4) functions to clear serotonin from the synaptic cleft. Many tricyclic antidepressants and serotonin selective reuptake inhibitors appear to act on this transporter. SSRIs function by increasing the amount of time serotonin remains in the synaptic cleft. The presence of active ST is vital for proper emotional development within the brain. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of serotonin transporter of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 516-630 mapping at the C-terminus of sodium-dependent serotonin transporter of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 516-630 mapping at the C-terminus of sodium-dependent serotonin transporter of human origin |
| Entrez Gene | 6532 |
|---|
Application
Western blot analysis of ST expression in rat brain tissue extract.| Application Notes | recommended for detection of serotonin transporter of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
