| Product Name | PDE8A Antibody (H-64) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 317-380 mapping within an internal region of PDE8A of human origin |
| Modification Notes | Phosphodiesterases (PDEs) are important for the downregulation of the intracellular level of the second messenger cyclic adenosine monophosphate (cAMP) by hydrolyzing cAMP to 5'AMP. Human cyclic GMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase (PDE2A) is expressed in cerebellum, neocortex, heart, kidney, placenta, lung, pulmonary artery, skeletal muscle and pancreas. PDE2A expression is detected in venous and capillary endothelial cells in cardiac and renal tissue. PDE8A is a high affinity cAMP-specific protein that is expressed in a wide variety of tissues including testis, ovary, small intestine, and colon. PDE8B is expressed specifically and abundantly in the thyroid gland and shares 65% sequence identity (83% similarity) with PDE8A. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PDE8A of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 317-380 mapping within an internal region of PDE8A of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 317-380 mapping within an internal region of PDE8A of human origin |
| Entrez Gene | 5151 |
|---|
| Application Notes | recommended for detection of PDE8A of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
