| Product Name | PTα Antibody (H-50) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-50 mapping at the N-terminus of PTα precursor of human origin |
| Modification Notes | Prothymosin a (PTå) is a nuclear protein that is widely expressed in mammalian tissues, including kidney, liver, spleen, normal lymphocytes, human T-cell leukemia virus-infected T cells and myeloma cells. The human PTå gene maps to chromosome 2 and encodes a protein that exhibits punctuated nuclear distribution, which correlates to transcription sites. PTå is a chromatin-remodeling protein that was initially thought to mediate T-lymphocyte maturation, but subsequently, has been shown to be involved in cell cycle progression, proliferation and cell differentiation. PTå is thought to be transported into the nucleus by the karyopherin b1-Rch-1 complex, where it associates with histones H2A, H2B, H3 and H4. Also, PTå is phosphorylated on Thr 7 and Thr 12 or 13 by Prothymosin å-phosphorylating kinase (PTåK) in a mitogen-activating pathway. The amino terminus of PTå is cleaved to produce a secreted, biologically active peptide thymosin å1, which may be used as an immunomodulator in cancer patients and patients with chronic active hepatitis, or as an immunoenhancer of vaccines in immunocompromised individuals. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Prothymosin α (PTα) precursor and active peptide of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-50 mapping at the N-terminus of PT&alpha precursor of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-50 mapping at the N-terminus of PTα precursor of human origin |
| Entrez Gene | 5757 |
|---|
| Application Notes | recommended for detection of Prothymosin α (PTα) precursor and active peptide of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
