| Product Name | RGS10 Antibody (H-159) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 15-173 mapping at the C-terminus of RGS10 of human origin |
| Modification Notes | Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. In mammals, G protein a, b and g poly-peptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their a subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four Ga GTPase-activating proteins (GAPs) have been identified and are designated RGS1 (regulator of G protein signaling), RGS4, RGS10 and GAIP (Ga-interacting protein). Each of these proteins has been shown to deactivate specific Ga isoforms by increasing the rate at which they convert GTP to GDP. RGS1, RGS4 and GAIP bind tightly to and exhibit GAP activity towards Ga i, Ga o, and Ga t, but not Ga s. RGS10 increases the GTP hydrolytic activity of several members of the Ga i sub-family, including Ga i-3, Ga z, and Ga o. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of RGS10 of mouse, rat and human origin by WB, IP, IF and ELISA partially cross-reactive with other RGS family members also reactive with additional species, including equine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 15-173 mapping at the C-terminus of RGS10 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 15-173 mapping at the C-terminus of RGS10 of human origin |
| Entrez Gene | 6001 |
|---|
| Application Notes | recommended for detection of RGS10 of mouse, rat and human origin by WB, IP, IF and ELISA partially cross-reactive with other RGS family members also reactive with additional species, including equine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
