| Product Name | U1 snRNP 70 Antibody (H-280) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 183-280 of U1 snRNP 70 of human origin |
| Modification Notes | U1 small nuclear ribonucleoprotein (U1 snRNP 70 or U1 70) is a component of the RNA spliceosome, a complex of proteins that are required for the precise excision of introns from pre-messenger RNA (pre-mRNA). U1 snRNP 70 specifically associates with the single stranded loop of hairpin 1 on U1 snRNA (small nuclear RNA). Like other snRNPs, U1 snRNP 70 contains a single RNA binding domain of 80-90 amino acids that is located within the central portion of the protein, and is both necessary and sufficient for the specific U1 snRNA binding in vitro. This interaction, which occurs independently of ATP, is essential for the commitment to the pre-mRNA splicing pathway, as it facilitates the association of other proteins with the spliceosome. U1 snRNP 70 is diffusely localized in the cytoplasm at the onset of mitosis and as mitosis progresses through telophase, U1 snRNP 70 accumulations in the daughter nuclei. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of U1 snRNP 70 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 183-280 of U1 snRNP 70 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 183-280 of U1 snRNP 70 of human origin |
| Entrez Gene | 6625 |
|---|
| Application Notes | recommended for detection of U1 snRNP 70 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
