Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes cells.Application
Western blot analysis of FGFR-4 expression in Caco-2 whole cell lysate.Application
Western blot analysis of FGFR-4 expression in Hep G2 whole cell lysate.Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate cancer showing membrane and cytoplasmic staining of tumor cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.Application
Antibodies tested include Bek (C-17): (A), FGFR-3 (C-15): (B) and FGFR-4 (C-16): (C). Kindly provided by Leslie Gold.Application
Immunofluorescence staining of methanol-fixed HeLa cells showing membrane staining.Application
Western blot analysis of FGFR-4 expression in HeLa whole cell lysate.| Product Name | FGFR-4 Antibody (C-16) AC |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the C-terminus of FGFR-4 of human origin |
| Modification Notes | Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor or FGFR-1, the Bek receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human FGFR-4, unlike the other FGFR genes, is alternatively spliced to produce only one isoform. It is expressed in fetal adrenal, lung, kidney, liver, pancreas, intestine, striated muscle and spleen tissues. FGFR-4 is also overexpressed in breast cancers and, subsequently, is a potential target for drug therapy. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of FGFR-4 of human origin by WB, IP, IF, IHC(P) and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the C-terminus of FGFR-4 of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the C-terminus of FGFR-4 of human origin |
| Entrez Gene | 2264 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes cells.
Application
Western blot analysis of FGFR-4 expression in Caco-2 whole cell lysate.
Application
Western blot analysis of FGFR-4 expression in Hep G2 whole cell lysate.
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate cancer showing membrane and cytoplasmic staining of tumor cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Application
Antibodies tested include Bek (C-17): (A), FGFR-3 (C-15): (B) and FGFR-4 (C-16): (C). Kindly provided by Leslie Gold.
Application
Immunofluorescence staining of methanol-fixed HeLa cells showing membrane staining.
Application
Western blot analysis of FGFR-4 expression in HeLa whole cell lysate.| Application Notes | recommended for detection of FGFR-4 of human origin by WB, IP, IF, IHC(P) and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
