Application
Western blot analysis of CD88 expression in non-transfected: (A) and human CD88 transfected: (B) 293T whole cell lysates.Application
Western blot analysis of CD88 expression in non-transfected: (A) and human CD88 transfected: (B) 293T whole cell lysates.Application
Western blot analysis of CD88 expression in U-937 (A) and HL-60/Mx-1 (B) whole cell lysates.| Product Name | CD88 Antibody (H-100) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 251-350 mapping at the C-terminus of CD88 of human origin |
| Modification Notes | CD88, also known as C5a receptor (C5aR), is a G protein-coupled integral membrane protein. CD88, which is expressed on neutrophils, monocytes, macrophages, hepatocytes and mast cells, as well as on various epithelial and endothelial cells, serves as a receptor for the inflammatory peptide C5a. Research studies suggest a role for CD88 in the inflammatory response. The binding of C5a to CD88 has been shown to elicit increased production of acute phase proteins in liver. In brain, an increased production of CD88 has been shown to be associated with inflammation. Research also indicates a role for C5a/C5aR in the pathogenesis of rheumatoid arthritis, as well as a heightened responsiveness of human bronchial epithelial cells (HBECs) to C5a upon exposure of these cells to cigarette smoke and other environmental irritants. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CD88 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 251-350 mapping at the C-terminus of CD88 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 251-350 mapping at the C-terminus of CD88 of human origin |
| Entrez Gene | 728 |
|---|
Application
Western blot analysis of CD88 expression in non-transfected: (A) and human CD88 transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of CD88 expression in non-transfected: (A) and human CD88 transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of CD88 expression in U-937 (A) and HL-60/Mx-1 (B) whole cell lysates.| Application Notes | recommended for detection of CD88 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
