| Product Name | p-LRP1 Antibody (Tyr 4507) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to phosphorylated Tyr 4507 of LRP1 of human origin |
| Modification | Phosphoralated |
| Modification Notes | Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRP’s (low density lipoprotein related proteins), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2, mediate the endocytosis of extracellular ligands. VLDLR and ApoER2 mediate the interaction of extracellular Reelin with cytosolic mDab1 (mammalian disabled protein), which activates a tyrosine kinase and regulates the migration of neurons along the radial glial fiber network. Mutations in LDLR cause the autosomal dominant disease familial hypercholesterolemia (FH), which promotes premature coronary atherosclerosis. LRP1 and megalin are implicated in Alzheimer’s disease, while LRP6 mediates Wnt/b-catenin signaling to control various developmental processes. Cubulin binds to megalin to mediate the uptake of specific ligands, including vitamin B12. LRP5 affects bone mass accrual during growth and mutations in LRP5 cause the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG). LRP1 phosphorylated on tyrosine is specifically associated with the cellular docking protein Shc and regulate ligand internalization. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of Tyr 4507 phosphorylated LRP1 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to phosphorylated Tyr 4507 of LRP1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to phosphorylated Tyr 4507 of LRP1 of human origin |
| Entrez Gene | 4035 |
|---|
| Application Notes | recommended for detection of Tyr 4507 phosphorylated LRP1 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
