| Product Name | ARHGAP22/24 Antibody (H-162) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 174-331 mapping within an internal region of ARHGAP22 of human origin |
| Modification Notes | GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in down regulation of their active form. ARHGAP22 (Rho GTPase activating protein 22), also known as RHOGAP2, is a 698 amino acid protein that localizes to the cytoplasm, and contains one Rho-GAP domain and one PH domain. ARHGAP22 functions as a GTPase-activating protein for Rac 1 converting it to an inactive GDP-bound state and, through its interaction with ZNF161 (VEZF1), is thought to be useful in transcription regulation. Multiple isoforms of ARHGAP22 exist due to alternative splicing events. ARHGAP24, also designated p73RhoGAP, RC-GAP72 or FILGAP is a 748 amino acid Rho GTPase activating protein implicated in cell polarity, cell morphology and cytoskeletal organization.ARHGAP24 exhibits differential expression as isoform 1 is widely expressed with highest levels observed in kidney while isoform 2 is primarily expressed in endothelial cells and has been shown to participate in the modulation of angiogenesis. The N-termini of ARHGAP22 and ARHGAP24 share significant amino acid sequence identity. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of ARGHAP22, ARHGAP24 and, to a lesser extent, ARHGAP25 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 174-331 mapping within an internal region of ARHGAP22 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 174-331 mapping within an internal region of ARHGAP22 of human origin |
| Entrez Gene | 58504 |
|---|
| Application Notes | recommended for detection of ARGHAP22, ARHGAP24 and, to a lesser extent, ARHGAP25 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
