| Product Name | PAF-R Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-300 of PAF-R of human origin |
| Modification Notes | Platelet-activating factor (PAF) is a pro-inflammatory lipid mediator that activates many cell types including leukocytes, platelets and vascular endothelial cells in response to cutaneous inflammation. PAF signaling is primarily directed through binding to the G protein-coupled PAF-receptors (PAF-R) and results in signal transduction by various pathways that are regulated by phospholipase C, phospholipase A2 and mitogen-activated protein kinases. Activation of PAF-R is associated with alterations in cell morphology, cyto-skeletal remodeling and expression of inflammatory modulators, including cyclo-oxygenase-2, interleukin (IL)-6 and IL-8. Expression of PAF-R is upregulated by PAF and gut flora in intestinal epithelium. PAF-R transcription is downregulated by glucocorticoids as a result of eosinophil depletion, suggesting that PAF-R may play a role in both host defenses and inflammatory responses. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PAF-R of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-300 of PAF-R of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-300 of PAF-R of human origin |
| Entrez Gene | 5724 |
|---|
| Application Notes | recommended for detection of PAF-R of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
