| Modification Notes |
The organic anion transporting polypeptide (OATP) family of proteins play a role in drug absorption, distribution and excretion. OATP proteins mediate the uptake of a broad range of substrates, including bile salts, hormones, drugs and antibiotics, and they are expressed in various tissues, such as gut, brain, kidney and liver. Oatp3, also known as Slco1a5 and Slc21a7, is a 670 amino acid member of the OATP protein family. As a multi-pass membrane protein, Oatp3 mediates the transport of organic anions, such as thyroid hormones and taurocholate during the absorption of bile acids in the liver.. The gene that encodes Oatp3 maps to mouse chromosome 6 G2. |