| Product Name | SLC4A8 Antibody (H-48) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 47-94 mapping within an N-terminal extracellular domain of SLC4A8 of human origin |
| Modification Notes | SLC4A8 (solute carrier family 4, sodium bicarbonate cotransporter, member 8), also known as NBC3, kNBC3 or NDCBE (Na+-Driven Chloride Bicarbonate Exchanger), is a member of the anion exchanger family and is predominantly expressed in brain and spinal column with moderate expression in thyroid, kidney and trachea. In the brain, SLC4A8 is found at high levels in the pyramidal cells of the hippocampus and the Purkinje cells of the cerebellum. Localizing to the membrane, SLC4A8 is an N-glycosylated, multi-pass membrane protein that plays an important role in intracellular pH regulation in neurons. More specifically, SLC4A8 functions as an electroneutral transporter and mediates the transport of bicarbonate and sodium ions across the membrane from the blood to the cell in exchange for cellular chloride. SLC4A8 is most closely related to NCBE and SLC4A7. Due to alternative splicing events, seven isoforms exist for SLC4A8. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SLC4A8 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 47-94 mapping within an N-terminal extracellular domain of SLC4A8 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 47-94 mapping within an N-terminal extracellular domain of SLC4A8 of human origin |
| Entrez Gene | 9498 |
|---|
| Application Notes | recommended for detection of SLC4A8 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
