Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing weak cytoplasmic and membrane staining in follicle cells, and strong cytoplasmic and membrane staining in non-follicle cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse lung tissue showing cytoplasmic and extracellular localization.Application
Western blot analysis of human recombinant IL-16.| Product Name | IL-16 Antibody (H-110) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 522-631 of IL-16 of human origin |
| Modification Notes | Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, intiate signal transduction cascades that elicit physiological changes in their target cells. Interleukin-16, or IL-16, is a cytokine that has chemoattractant activity on CD4+ T lymphocytes. It has long been known that eosinophils and CD4+ T lymphocytes are recruited to sites of allergic inflammation, but the molecular mechanism was poorly understood. IL-16, also referred to as lymphocyte chemoattractant factor, is secreted by activated eosinophils as part of the allergic response along with RANTES, an additional cytokine (7). Once bound to its cognate receptor, CD4, IL-16 initiates a signal cascade that results in the activation of the PKC family. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of IL-16 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 522-631 of IL-16 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 522-631 of IL-16 of human origin |
| Entrez Gene | 3603 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing weak cytoplasmic and membrane staining in follicle cells, and strong cytoplasmic and membrane staining in non-follicle cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse lung tissue showing cytoplasmic and extracellular localization.
Application
Western blot analysis of human recombinant IL-16.| Application Notes | recommended for detection of IL-16 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
