| Product Name | Syntaxin 11 Antibody (H-120) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 147-266 mapping near the C-terminus of Syntaxin 11 of human origin |
| Modification Notes | Syntaxins, a family of proteins involved in the fusion of synaptic vesicles with the plasma membrane, display broad tissue distribution and contain C-terminal hydrophobic domains that direct them to their respective intracellular compartments. Syntaxin 11, also known as STX11, FHL4, HLH4 or HPLH4 is a 287 amino acid protein that contains one t-SNARE coiled-coil homology domain and localizes to the membrane of the trans-golgi network. Interacting with SNAP 23 and VAMP, Syntaxin 11 functions to regulate protein transport between the trans-golgi network and late endosomes. Defects in the gene encoding Syntaxin 11 are the cause of familial hemophagocytic lymphohistiocytosis type 4 (FHL4), a genetically heterogeneous autosomal recessive disorder that is characterized by fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, seizures, cranial nerve deficits and ataxia. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Syntaxin 11 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 147-266 mapping near the C-terminus of Syntaxin 11 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 147-266 mapping near the C-terminus of Syntaxin 11 of human origin |
| Entrez Gene | 8676 |
|---|
| Application Notes | recommended for detection of Syntaxin 11 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
