| Product Name | Slac2-c Antibody (H-100) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 760-859 mapping at the C-terminus of Slac2-c of human origin |
| Modification Notes | Slac2-c (Slp homolog lacking C2 domains c), also known as SLAC2C or MYRIP (Myosin-VIIa- and Rab-interacting protein) is a Rab effector protein that is expressed in a variety of tissues including brain, heart, skin and liver. Found in the basal microvilli of retinal pigment cells and in pre- and post-synaptic areas in photoreceptor cells , Slac2-c is involved in melanosome transport and functions to link Rab 27a with the actin-based motor proteins Myosin Va and Myosin VIIa. Once linked, the Myosins are able to transport Rab 27a to retinal melanosomes, thereby linking the actin cytoskeleton with the melanosome membrane. Slac2-c contains one FYVE-type zinc finger and one Rab-binding domain and is able to bind actin-like proteins through its conserved C-terminal region. Additionally, Slac2-c is thought to regulate the final steps of insulin exocytosis by mediating the interaction of secretory granules with the cortical actin cytoskeleton. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Slp homolog lacking C2 domains c of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 760-859 mapping at the C-terminus of Slac2-c of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 760-859 mapping at the C-terminus of Slac2-c of human origin |
| Entrez Gene | 25924 |
|---|
| Application Notes | recommended for detection of Slp homolog lacking C2 domains c of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
