| Product Name | FIC1 Antibody (H-91) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1161-1251 mapping at the C-terminus of FIC1 of human origin |
| Modification Notes | FIC1 is a 1,251 amino acid protein encoded by the human gene ATP8B1 and belongs to the cation transport ATPase (P-type) family, type IV subfamily. FIC1 is a multi-pass membrane protein believed to play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and in the maintenance of asymmetric distribution of phospholipids in the canicular membrane. It may also have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa, or both. FIC1 is found in most tissues except brain and skeletal muscle and is most abundant in pancreas and small intestine. Defects in the ATP8B1 gene are the cause of intrahepatic cholestasis (PFIC1), also known as Byler disease. PFIC1 is an autosomal recessive disorder, characterized by early infancy cholestasis, that may be initially episodic but progresses to malnutrition, growth retardation and end-stage liver disease before adulthood. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of FIC1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1161-1251 mapping at the C-terminus of FIC1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1161-1251 mapping at the C-terminus of FIC1 of human origin |
| Entrez Gene | 5205 |
|---|
| Application Notes | recommended for detection of FIC1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
