| Modification Notes |
The organic anion transporter family of proteins mediate hepatic uptake of cardiac glycosides. OATP-I (organic anion transporter F), also known as SLCO6A1 (solute carrier organic anion transporter family member 6A1), gonad-specific transporter (GST), cancer/testis antigen 48 (CT48) or SLC21A14 (solute carrier family 21 member 19), is a 719 amino acid member of the organic anion transporter protein family. As a multi-pass membrane protein, OATP-I is thought to mediate the Na+-independent transport of organic anions. OATP-I is highly expressed in testis, with lower expression found in brain, placenta and spleen. OATP-I is expressed as three isoforms produced by alternative splicing events. |