| Product Name | MAP LC3α/β Antibody (H-47) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 58-104 mapping within an internal region of MAP LC3α of human origin |
| Modification Notes | Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and in maintaining the balance between neuronal plasticity and rigidity. MAP-light chain 3 beta (MAP-LC3∫) and MAP-light chain 3 alpha (MAP-LC3å) are subunits that can associate with either MAP-1A or MAP-1B. While MAP-LC3∫ is essential for autophagy and is associated with autophagosome membranes after processing, MAP LC3å is involved in the formation of autophagosomal vacuoles and is localized to the intracytoplasmic membrane. MAP LC3å is expressed as two alternatively spliced isoforms that are expressed in testis, brain, heart, liver and skeletal muscle, but are absent in thymus and peripheral blood leukocytes. MAP LC3∫, which exists in a cytosolic and a membrane-bound form, may also be involved in formation of autophagosomal vacuoles and is expressed primarily in heart, testis, brain and skeletal muscle. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MAP LC3α and to a lesser extent MAP LC3β of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 58-104 mapping within an internal region of MAP LC3&alpha of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 58-104 mapping within an internal region of MAP LC3α of human origin |
| Entrez Gene | 84557 |
|---|
| Application Notes | recommended for detection of MAP LC3α and to a lesser extent MAP LC3β of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
