| Modification Notes |
NHPX, also known as NHP2L1 (NHP2 non-histone chromosome protein 2-like 1), FA-1, 15.5K, OTK27, SNU13, SPAG12 or SNRNP15-5, is a 128 amino acid protein belonging to the ribosomal protein L7Ae family. NHPX localizes to the nucleus, mainly concentrated in the dense fibrillar component of the nucleolus. Ubiquitously expressed, NHPX binds to the 5’-stem-loop of U4 snRNA and may be involved in the late stage of spliceosome assembly. Following RNA binding, NHPX undergoes a conformational change and is recruited to introns, where NHPX is required for the subsequent recruitment of PRPF31 and the activation of the spliceosome complex. NHPX is expressed as two isoforms produced by alternative splicing. |