| Product Name | Septin 8 Antibody (H-58) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 426-483 mapping at the C-terminus of Septin 8 of human origin |
| Modification Notes | Septins are members of a conserved family of cytoskeletal GTPases, specifically belonging to the large superclass of P-loop GTPases. Septin proteins form homo- and hetero-oligomeric polymers that accumulate into higher-order filaments which may function as dynamic protein scaffolds. Septins play an important role in vesicle trafficking, apoptosis, cytoskeleton remodeling, infection, neurodegeneration, neoplasia and cytokinesis. Septin 8 is a 508 amino acid protein that is expressed in the brain, cardiovascular regions, prostate, testis and ovary. Septin 8 interacts with both Septin 5 and cell division cycle related-1 (CDCrel-1). Septin 8 may play an important role in the functional regulation of hPFTAIRE1, a member of the Cdc2-related kinase family that is localized in cytoplasm. Septin 8, Septin 4 and Septin 5 surround a-granules, implicating these three septins as components of the septin complex in platelets and contributing to platelet biology. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Septin 8 of mouse and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 426-483 mapping at the C-terminus of Septin 8 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 426-483 mapping at the C-terminus of Septin 8 of human origin |
| Entrez Gene | 23176 |
|---|
| Application Notes | recommended for detection of Septin 8 of mouse and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
