Application
Immunofluorescence staining of normal mouse heart frozen section showing membrane staining.| Product Name | P/Q-type Ca++ CP α1A Antibody (H-90) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 2225-2314 mapping within a cytoplasmic domain of P/Q-type Ca++ CP α1A of human origin |
| Modification Notes | Voltage-dependent Ca2+ channels mediate Ca2+ entry into excitable cells in response to membrane depolarization, and they are involved in a variety of Ca2+-dependent processes, including muscle contraction, hormone or neurotransmitter release and gene expression. Calcium channels are highly diverse, multimeric complexes composed of an å-1 subunit, an intracellular ∫ subunit, a disulfide linked å-2/∂ subunit and a transmembrane © subunit. Ca2+ currents are characterized on the basis of their biophysical and pharmacologic properties and include L-, N-, T-, P-, Q-, and R- types. P/Q-type Ca2+ channels are localized to presynaptic nerve terminals and are crucial elements in the coupling of neuronal excitation to secretion. P/Q-type Ca2+ currents initiate a rapid synaptic transmission that is regulated through G proteins, SNARE proteins, and protein phospho-rylation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of P/Q-type Ca++ CP α1A and, to a lesser extent, R-type Ca++ CP α1E and N-type Ca++ CP α1B of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 2225-2314 mapping within a cytoplasmic domain of P/Q-type Ca++ CP &alpha 1A of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 2225-2314 mapping within a cytoplasmic domain of P/Q-type Ca++ CP α1A of human origin |
| Entrez Gene | 773 |
|---|
Application
Immunofluorescence staining of normal mouse heart frozen section showing membrane staining.| Application Notes | recommended for detection of P/Q-type Ca++ CP α1A and, to a lesser extent, R-type Ca++ CP α1E and N-type Ca++ CP α1B of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
