| Product Name | DSCR 2 Antibody (L-15) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of DSCR 2 of human origin |
| Modification Notes | An extra copy of chromosome 21, the smallest human autosome chromosome, results in Down syndrome. The Down Syndrome critical region (DSCR) maps specifically to chromosme 21q22.2 and includes several genes which are likely associated with the pathogenesis of Down syndrome. DSCR 2 (down syndrome critical region protein 2), also known as Proteasome assembly chaperone 1, is a 288 amino acid protein that acts as a 20S proteasome-assembling chaperone and forms heterodimers with 20S proteasome precursors. Interestingly, DSCR 2 inhibits transcription of PPAR∫ and co-expression of these two proteins leads to the formation of DSCR 2 aggregates. With expression in adult colon, leukocytes, brain, testis and breast, DSCR 2 is localized to the endoplasmic reticulum and cytoplasm. There are two isoforms of DSCR 2 that exist as a result of alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of DSCR 2 of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with other DSCR family members also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of DSCR 2 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of DSCR 2 of human origin |
| Entrez Gene | 8624 |
|---|
| Application Notes | recommended for detection of DSCR 2 of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with other DSCR family members also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
