| Product Name | DHCR24 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-300 mapping at the N-terminus of DHCR24 of human origin |
| Modification Notes | Dehydrocholesterol reductase (DHCR) proteins are involved in cholesterol bio-synthesis. DHCR7, also designated sterol Delta-7 reductase or 7-DHC reductase, reduces the C7-C8 double bond of 7-dehydrocholesterol. It is a multi-pass membrane protein localizing to the endoplasmic reticulum (ER). Defects in the DHCR7 gene can cause Smith-Lemli-Opitz syndrome (SLOS), an autosomal recessive disorder of sterol metabolism. DHCR24 acts as a catalyst for the reduction of the Delta-24 double bond of sterol intermediates. DHCR24, also designated 3-b-hydroxysterol Delta-24 reductase or seladin-1, binds to FAD and is predominantly expressed in adrenal gland and brain. It is a single-pass membrane protein localizing to the ER or Golgi apparatus. Defects in the DHCR24 gene cause cause the autosomal recessive disorder desmosterolosis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of DHCR24 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-300 mapping at the N-terminus of DHCR24 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-300 mapping at the N-terminus of DHCR24 of human origin |
| Application Notes | recommended for detection of DHCR24 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
