Application
Western blot analysis of NFATc2IP expression in Jurkat (A) and K-562 (B) whole cell lysates.Application
Western blot analysis of NFATc2IP expression in Jurkat nuclear extract.| Product Name | NFATc2IP Antibody (H-199) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 221-419 mapping at the C-terminus of NFATc2IP of human origin |
| Modification Notes | NFATc2IP (NFATC2-interacting protein), also known as NIP45, is a 419 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one ubiquitin-like domain. Interacting with NFATc2, TRAF1 and TRAF2, NFATc2IP plays a role in the inducible expression of cytokines in T-cells, specifically by enhancing NFATc2-induced interleukin (IL) production. NFATc2IP exists as three alternatively spliced isoforms and is subject to post-translational methylation; an event which augments NFATc2IP-regulated cytokine production. The gene encoding NFATc2IP maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NFATc2IP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 221-419 mapping at the C-terminus of NFATc2IP of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 221-419 mapping at the C-terminus of NFATc2IP of human origin |
| Entrez Gene | 84901 |
|---|
Application
Western blot analysis of NFATc2IP expression in Jurkat (A) and K-562 (B) whole cell lysates.
Application
Western blot analysis of NFATc2IP expression in Jurkat nuclear extract.| Application Notes | recommended for detection of NFATc2IP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
