| Modification Notes |
SLC2A4RG (SLC2A4 regulator), also known as Huntington disease gene regulatory region-binding protein 1 and GLUT4 enhancer factor, is a 387 amino acid transcription factor that is involved in Glut4 and HD gene transactivation. In cooperation with MEF-2, SLC2A4RG binds to domain I of the Glut4 promoter to regulate transcription of Glut4. Interestingly, after a single bout of exercise, there is an increase in DNA binding activities of both SLC2A4RG and MEF-2, which leads to an increase in transcription of Glut4. This is significant because overexpression of Glut4 in skeletal muscle has shown to improve glucose homeostasis and enhance insulin action. Also, by recognizing the 5’-GCCGGCG-3’ DNA sequence motif of the Huntington’s disease (HD) promoter, SLC2A4RG regulates transcription of the HD gene. Ubiquitously expressed with highest expression in skeletal muscle, liver, kidney, heart and pancreas, SLC2A4RG shuttles between the cytoplasm and nucleus and contains a C2H2-type zinc finger that is involved in DNA binding. There are two isoforms of SLCA4RG that are produced as a result of alternative splicing. |
