| Product Name | CDK2AP1 Antibody (H-57) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 20-76 mapping within an internal region of CDK2AP1 of human origin |
| Modification Notes | CDK2AP1 (also designated p12 and DOC-1) is a growth suppressor that binds to and inhibits DNA pol å/primase. When bound, CDK2AP1 affects the initiation step, but not the elongation phase, of replication. CDK2AP1 also binds to cyclin-dependent kinase 2 (Cdk2) and targets it for proteolysis. CDK2AP1 promotes cell cycle arrest by regulating the S phase of the cycle, and may trigger apoptosis. The growth factor TGF∫1 transcriptionally-induces CDK2AP1 expression, which, in turn, mediates the growth inhibitory activity of TGF∫1 by modulating Cdk2 activities and pRB phosphorylation. Due to its ability to trigger apoptosis, CDK2AP1 may be a good candidate for a tumor suppressor in oral cancer. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CDK2AP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 20-76 mapping within an internal region of CDK2AP1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 20-76 mapping within an internal region of CDK2AP1 of human origin |
| Application Notes | recommended for detection of CDK2AP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
