| Product Name | GATAD2A Antibody (H-162) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 186-275 mapping within an internal region of GATAD2A of human origin |
| Modification Notes | GATAD2A (GATA zinc finger domain containing 2A), also known as p66å, is a ubiquitously expressed, highly conserved protein that is essential for development. GATAD2A contains a GATA-type zinc finger and is a component of the NuRD (nucleosome remodeling and histone deacetylation) complex along with MBD2, HDAC1 and HDAC2. The NuRD complex is associated with ATP-dependent chromatin-remodeling and histone deacetylase activity. GATAD2A interacts with MBD2 and MBD3 and colocalizes with MBD2 in nuclear speckles. This interaction enhances repression mediated by MBD2 and allows for the interaction with histone tails. GATAD2A contains two domains involved in transcriptional repression. For functional repressor activity, GATAD2A requires SUMOylation at Lys-30 and Lys-487. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of GATAD2A of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with GATAD2B also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 186-275 mapping within an internal region of GATAD2A of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 186-275 mapping within an internal region of GATAD2A of human origin |
| Entrez Gene | 54815 |
|---|
| Application Notes | recommended for detection of GATAD2A of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with GATAD2B also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
