| Modification Notes |
The Ly-6 (Lymphocyte antigen 6) alloantigens represent a family of phosphatidylinositol-anchored proteins that play a role in the process of T lymphocyte activation. Ly-6 family members share amino acid homology throughout a distinctive cysteine rich protein domain that incorporates O-linked carbohydrates. During hematopoiesis, murine Ly-6 molecules have unique patterns of tissue expression, from multipotential stem cells to lineage committed precursor cells, and, on specific leukocyte sub-populations in the peripheral lymphoid tissues. Ly-6K (lymphocyte antigen 6 complex, locus K), also known as CO16, is a 165 amino acid protein that is both secreted and lipid-anchored to the cell membrane and contains one UPAR/Ly6 domain. Expressed specifically in testis, Ly-6K is thought to play a role in cell growth and may also be a potential marker for various types of carcinomas. |