| Product Name | Pegasus Antibody (H-220) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 163-382 mapping near the C-terminus of Pegasus of human origin |
| Modification Notes | Ikaros family members, including Ikaros and Helios, are nuclear factors that colocalize with DNA replication machinery components in higher-order chromatin structures and respond to signaling events, such as T-cell activation. Helios and Ikaros bind to similar DNA sequences and they function as hemopoietic-specific transcription factors. Members of the Ikaros family contain zinc-finger domains that are involved in DNA-binding and in the formation of homodimers and heterodimers between Ikaros family members. Pegasus, also known as zinc finger protein Ikaros 5, is a 419 amino acid transcriptional repressor. Localized to the nucleus, Pegasus binds to the 5'GNNTGTNG-3' DNA core sequence. Pegasus contains 5 C2H2-type zinc finger domains. The C-terminal zinc finger domains participate in homodimerization and the N-terminal domains participate in heterodimerization with Ikaros family members and DNA binding. Pegasus is expressed in many tissues including kidney, heart, skeletal muscle, brain and liver. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Pegasus of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 163-382 mapping near the C-terminus of Pegasus of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 163-382 mapping near the C-terminus of Pegasus of human origin |
| Entrez Gene | 64376 |
|---|
| Application Notes | recommended for detection of Pegasus of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
