Application
Western blot analysis of LASP-1 expression in SK-OV-3 whole cell lysate.| Product Name | LASP-1 Antibody (H-91) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 123-213 mapping within an internal region of LASP-1 of human origin |
| Modification Notes | LASP-1 (LIM and SH3 domain protein 1), also known as MLN50, is a 261 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one SH3 domain, one LIM zinc-binding domain and two nebulin repeats. Expressed as two alternatively spliced isoforms, LASP-1 interacts with F-Actin and plays an important role in the regulation of Actin-associated cytoskeletal organization. LASP-1 is subject to post-translational phosphorylation, an event which may regulate Actin-related ion transport activities in epithelial cells. Overexpression of LASP-1 is associated with breast cancer, suggesting a role for LASP-1 in tumor transformation and metastasis. The gene encoding LASP-1 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of LASP-1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 123-213 mapping within an internal region of LASP-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 123-213 mapping within an internal region of LASP-1 of human origin |
| Entrez Gene | 3927 |
|---|
Application
Western blot analysis of LASP-1 expression in SK-OV-3 whole cell lysate.| Application Notes | recommended for detection of LASP-1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
