| Product Name | SerpinB6 Antibody (H-48) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 203-250 mapping within an internal region of SerpinB6 of human origin |
| Modification Notes | Members of the serine protease inhibitor superfamily are collectively called serpins. Inhibitory serpins typically form 1:1 complexes with their target proteases, which are often SDS-stable associations. SerpinB6, also known as protease inhibitor 6 (PI-6) in human and Spi3 in mouse, is a serine protease inhibitor with both antitrypsin and antichymotrypsin activity. Although most serpins are secreted glycoproteins that regulate extracellular proteases, SerpinB6 lacks classical nuclear localization, exhibiting primarily cytoplasmic distribution, and is not secreted by conventional methods. SerpinB6 is present in most tissues in capillary endothelial cells, platelets, epithelial cells, monocytes and granulocytes. SerpinB6 binds the arginine-selective protease human kallikrein 2 (hK2) as well as the monocyte and granulocyte azurophilic granule protease cathepsin G. In mouse, there are three SerpinB6 genes, namely SerpinB6a, SerpinB6b and SerpinB6c. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SerpinB6 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 203-250 mapping within an internal region of SerpinB6 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 203-250 mapping within an internal region of SerpinB6 of human origin |
| Entrez Gene | 5269 |
|---|
| Application Notes | recommended for detection of SerpinB6 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
