| Product Name | GRAIL Antibody (H-91) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 338-428 mapping at the C-terminus of GRAIL of human origin |
| Modification Notes | GRAIL, also known as ring finger protein 128, is a 428 amino acid type I transmembrane protein localized to the intracytoplasmic membrane. GRAIL contains a protease-associated (PA) domain and a RING finger domain, which binds to E2 ubiquitin-conjugating enzymes. When under anergic conditions, GRAIL functions as an E3 ubiquitin-protein ligase that inhibits IL-2, IL-4 and various other cytokines. GRAIL is also thought to be involved in the patterning of the dorsal ectoderm during development. Expressed in an asymmetric perinuclear punctate manner, GRAIL colocalizes with Rab 7, GRP 78 and Syntaxin 5. GRAIL is expressed as 2 isoforms produced by alternative splicing. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of GRAIL of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 338-428 mapping at the C-terminus of GRAIL of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 338-428 mapping at the C-terminus of GRAIL of human origin |
| Entrez Gene | 79589 |
|---|
| Application Notes | recommended for detection of GRAIL of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
