| Product Name | 3β-HSD7 Antibody (H-137) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 233-369 mapping at the C-terminus of 3β-HSD7 of human origin |
| Modification Notes | 3 beta-hydroxysteroid dehydrogenase (3∫-HSD), also known as HSD3B1 or HSDB3, is a bifunctional enzyme that plays a crucial role in the synthesis of all classes of hormonal steroids. 3 beta-hydroxysteroid dehydrogenase type 7 (3∫-HSD7) is a 369 amino acid protein belonging to the 3∫-HSD family. Localized to the membrane of the endoplasmic reticulum, 3∫-HSD7 plays an active role in the initial stages of bile synthesis from cholesterol. 3∫-HSD7 catalyzes the oxidative conversion of ∂5-ene-3-beta-hydroxy steroid and is active against 7-alpha hydrosylated sterol substrates. Mutations in the gene encoding 3∫-HSD7 are associated with congenital bile acid synthesis defect, which leads to neonatal cholestasis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of 3β-HSD7 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 233-369 mapping at the C-terminus of 3&beta -HSD7 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 233-369 mapping at the C-terminus of 3β-HSD7 of human origin |
| Entrez Gene | 80270 |
|---|
| Application Notes | recommended for detection of 3β-HSD7 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
