Application
Western blot analysis of IL-18BP expression in HeLa (A), K-562 (B) and Daudi (C) whole cell lysates.| Product Name | IL-18BP Antibody (H-61) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 30-90 mapping within an internal region of IL-18BP of human origin |
| Modification Notes | IL-18 (also referred to as IL-1©) has been shown to augment the secretion of IFN-© from T lymphocytes and to increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1å and IL-1∫, respectively, over the twelve ∫-strands of the ∫-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1∫ pro-domain, which must be cleaved by the serine protease ICE for optimal secretion and biological activity. IL-18, which was originally described as IGIF (IFN-©-inducing factor), IL-18 is induced in mouse liver subsequent to challenge with lipopolysaccharide (LPS). IL-18 binding protein (IL-18BP) functions as an inhibitor of the early Th1 response by binding to IL-18 and inhibiting IFN-© production. IL-18BP is a member of the immunoglobulin superfamily and shares some homology to IL-1RII. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of IL-18BP of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 30-90 mapping within an internal region of IL-18BP of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 30-90 mapping within an internal region of IL-18BP of human origin |
| Entrez Gene | 10068 |
|---|
Application
Western blot analysis of IL-18BP expression in HeLa (A), K-562 (B) and Daudi (C) whole cell lysates.| Application Notes | recommended for detection of IL-18BP of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
