| Modification Notes |
Cytochrome P450 proteins are heme-thiolate monooxygenases that mediate NADPH-dependent electron transport and function to oxidize a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Specifically, Cytochrome P450s are responsible for metabolizing arachidonic acid to hydroxyeicosatetraenoic acid (a regulator of blood pressure) and epoxyeicosatrienoic acid (a molecule involved in signaling events). The CYP4A family of Cytochrome P450 proteins contains two human proteins and multiple murine proteins, including CYP4A10, CYP4A12A, CYP4A12B, CYP4A14, CYP4A29, CYP4A31, CYP4A32 and CYP4A30B, all of which may be involved in the metabolism of fatty acids. |