| Modification Notes |
The development of lipomas, benign tumors composed of fatty tissues, have been linked to breakpoints in the HMGI-C gene. LHFP (lipoma HMGIC fusion partner) is a 200 amino acid multi-pass membrane protein that acts as a fusion partner with HMGI-C in a lipoma with the translocation t(12;13)(q13-q15;q12). Located on chromosome 13, the gene encoding LHFP is in a region that is frequently targeted by chromosomal aberrations in lipomas. The LHFP/HMGIC fusion transcript expresses 69 amino acids encoded by frame-shift LHFP sequences and three DNA binding domains of HMGIC. The mouse homolog of LHFP shares 94% sequence similarity with the human protein. With the exception of peripheral blood leukocytes, LHFP is ubiquitously expressed. |