| Modification Notes |
Choline is an essential nutrient that is required for the synthesis of both acetylcholine, a neurotransmitter found in cholinergic nerve terminals, and phosphatidylcholine, a key component of cell membranes. Choline deficiencies are associated with defects in cell growth and have been implicated in disorders such as Alzheimer’s and Parkinson’s disease. The choline transporter-like protein family (CTL) are solute carriers that transport choline, a compound which is not able to permeate cells, across the cell membrane. CTL2, also called SLC44A2 (solute carrier family 44 member 2), is a multi-pass membrane protein expressed in cells of the inner ear. CTL2 is a possible candidate for autoimmune hearing loss in humans. |