Application
Immunofluores-cence staining of methanol-fixed HeLa cells showing cytoplasmic localization. Antibody tested: TMEM126A (S-13): .Application
Western blot analysis of TMEM126A expression in mouse liver (A) and mouse pancreas (B) tissue extracts.Application
Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.| Product Name | TMEM126A Antibody (S-13) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of TMEM126A of human origin |
| Modification Notes | TMEM126A (transmembrane protein 126A) is a 195 amino acid multi-pass membrane protein that is encoded by a gene which maps to human chromosome 11 and may be involved in the pathogenesis of autosomal-recessive nonsyndromic optic atrophy. With approximately 135 million base pairs and 1,400 genes, chromosome 11 comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TMEM126A of human and, to a lesser extent mouse origin by WB, IP, IF and ELISA non cross-reactive with other TMEM family members also reactive with additional species, including equine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of TMEM126A of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of TMEM126A of human origin |
| Entrez Gene | 84233 |
|---|
Application
Immunofluores-cence staining of methanol-fixed HeLa cells showing cytoplasmic localization. Antibody tested: TMEM126A (S-13): .
Application
Western blot analysis of TMEM126A expression in mouse liver (A) and mouse pancreas (B) tissue extracts.
Application
Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.| Application Notes | recommended for detection of TMEM126A of human and, to a lesser extent mouse origin by WB, IP, IF and ELISA non cross-reactive with other TMEM family members also reactive with additional species, including equine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
