| Product Name | Rad21 Antibody (H-210) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 143-352 mapping within an internal region of Rad21 of human origin |
| Modification Notes | Rad21 is one of the major cohesin subunits that holds sister chromatids together until anaphase, when proteolytic cleavage by separase, a caspase-like enzyme, allows chromosomal separation. RAD21 interacts with REC8 to form a cohesin complex that functions in sister chromatid alignment. RAD21 is also involved in the repair of double-strand breaks in DNA and is essential for mitotic growth. Rad 21 undergoes a C-terminal cleavage induced by diverse stimuli right before apoptosis. The cleavage product migrates to the cytoplasm and is involved in early events in the apoptotic pathway and it amplifiies the cell death signal in a positive-feedback manner. The RAD21 gene is related to the invasion and metastasis of cancer cells, and RAD21 is a potential target for cancer therapeutics that may enhance the anti-tumor activity of chemotherapeutic agents acting through the induction of DNA damage. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Rad21 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 143-352 mapping within an internal region of Rad21 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 143-352 mapping within an internal region of Rad21 of human origin |
| Entrez Gene | 5885 |
|---|
| Application Notes | recommended for detection of Rad21 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
