| Modification Notes |
Isthmin, also known as Ism or Ism1, is a 454 amino acid secreted protein belonging to the Isthmin family. Isthmin contains an AMOP motif and a thrombospondin type-1 domain, the latter of which is shared by several mammalian proteins with diverse biological functions, including cell adhesion, angiogenesis and patterning of developing nervous system. Isthmin has also been identified as a novel angiogenesis inhibitor of tumor growth in mice. The gene encoding Isthmin is located on mouse chromosome 2 and human chromosome 20. Human chromosome 20 is comprised of approximately 2% of the human genome and contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception. |
