| Product Name | ARH3 Antibody (H-315) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 18-332 mapping within an internal region of ARH3 of human origin |
| Modification Notes | ARH3 (ADP-ribosylhydrolase 3), also known as ADPRHL2 (ADP-ribosylhydrolase like 2), is a 363 amino acid protein that localizes to mitochondria, as well as to both the cytoplasm and the nucleus, and belongs to the ADP-ribosylglycohydrolase family. Expressed ubiquitously, ARH3 uses magnesium as a cofactor to catalyze the hydrolysis of poly(ADP-ribose) that is synthesized after DNA damage. Via its catalytic activity, ARH3 generates ADP-ribose from poly(ADP-ribose) and is thought to play an important role in the maintenance of normal neuronal cell function. The gene encoding ARH3 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ARH3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 18-332 mapping within an internal region of ARH3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 18-332 mapping within an internal region of ARH3 of human origin |
| Entrez Gene | 54936 |
|---|
| Application Notes | recommended for detection of ARH3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
