| Product Name | PIP5KIII Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1803-2098 mapping at the C-terminus of PIP5KIII of human origin |
| Modification Notes | The PIP5K family is divided into type I, type II and type III proteins, each of which phosphorylates distinct substrates. The PIP5K proteins contain an activation loop which determines their enzymatic specificity and subcellular targeting. Phosphatidylinositol-4-phosphate-5-kinase, also known as PIP5KIII or PIP5K3, synthesizes phosphatidylinositol-4,5-bisphosphate, which regulates various processes including cell proliferation, survival, membrane trafficking and cytoskeletal organization. Located in the membrane of the endosome, PIP5KIII contains an FYVE-type zinc finger and catalyzes the rate-limiting step in the production of phosphatidylinositol, a phospholipid that plays a role in Actin dynamics. Defects in the gene encoding PIP5KIII lead to corneal fleck dystrophy (CFD), an autosomal disorder in which small white flecks are found throughout the corneal stroma.. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PIP5KIII of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1803-2098 mapping at the C-terminus of PIP5KIII of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1803-2098 mapping at the C-terminus of PIP5KIII of human origin |
| Entrez Gene | 200576 |
|---|
| Application Notes | recommended for detection of PIP5KIII of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
