| Product Name | Angiomotin Antibody (H-66) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 174-279 mapping within an internal region of Angiomotin of human origin |
| Modification Notes | Angiomotin, also known as AMOT, is a 1,084 amino acid protein that belongs to the motin family of angiostatin binding proteins. Members of the motin family contain conserved coiled-coil domains and PDZ binding motifs at their C-termini. Expressed in skeletal muscle and placenta, Angiomotin localizes to the cell surface at tight junctions and is believed to be involved in tight junction maintenance. Angiomotin binds to angiostatin and plays a vital role in angiogenesis, promoting tubule formation and growth factor-induced migration of endothelial cells. This suggests that Angiomotin may be an important player in tumor angiogenesis and could serve as a potential therapeutic target in cancer. Due to alternative splicing events, two Angiomotin isoforms exist, namely p130 and p80. The p130 isoform exhibits a different expression pattern from the p80 isoform and is able to interact with F-actin as well as induce Actin fiber formation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Angiomotin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 174-279 mapping within an internal region of Angiomotin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 174-279 mapping within an internal region of Angiomotin of human origin |
| Entrez Gene | 154796 |
|---|
| Application Notes | recommended for detection of Angiomotin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
