| Product Name | Cdt2 Antibody (H-240) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-240 mapping at the N-terminus of Cdt2 of human origin |
| Modification Notes | WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. Cdt2, also known as DTL (denticleless homolog), CDW1, DCAF2, L2DTL or RAMP, is a 730 amino acid protein that localizes to both the cytoplasm and the nuclear membrane and contains seven WD repeats. Expressed in testis, placenta, bone marrow, thymus and skeletal muscle, Cdt2 is required for DNA damage-induced Cdt1 proteolysis and is also thought to play an essential role in DNA replication and cell proliferation. Upon DNA damage, Cdt2 is subject to phosphorylation, probably by ATM or ATR. Two isoforms of Cdt2 exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Cdt2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-240 mapping at the N-terminus of Cdt2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-240 mapping at the N-terminus of Cdt2 of human origin |
| Entrez Gene | 51514 |
|---|
| Application Notes | recommended for detection of Cdt2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
